Casting producers are looking for charismatic individuals who have the desire to change their lives forever and vie for this once-in-a-lifetime opportunity to lose weight and compete for a grand prize of $250,000. Candidates must be at least 18 years of age and legal residents of the United States. For those who are unable to attend a casting call, information on how to apply to the show and submit a videotape is available on http://www.nbc.com/casting#bl16 and www.thebiggestlosercasting.com.